Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat
Identifieur interne : 005159 ( Main/Exploration ); précédent : 005158; suivant : 005160Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat
Auteurs : Mary Anne Campbell [Canada] ; S. Bandiera [Canada] ; L. Robertson [Canada] ; A. Parkinson [Canada] ; S. Safe [Canada]Source :
- Toxicology [ 0300-483X ] ; 1981.
Abstract
Administration of octachloronaphthalene to immature male Wistar rats resulted in a dose-dependent increase in several enzymic, electrophoretic and spectral parameters associated with induction of the hepatic microsomal enzymes. Compared to corn-oil (control) treated animals octachloronaphthalene (150 μmol · kg−1 induced hepatic cytochrome P-450 (1.5-fold), benzo [a]pyrene hydroxylase (18-fold) and 4-chlorobiphenyl hydroxylase (18-fold) enzyme activities. In addition to increases in the relative peak intensities of the reduced microsomal cytochrome P-450 : CO and ethylisocyanide (EIC) difference spectra the peak maxima were observed at 448.5 and 452.2/428.0 nm, respectively. The effects of administering octachloronaphthalene to the rat were similar to those observed after pretreatment with 3-methylcholanthrene (MC) and electrophoresis of the induced microsomal proteins showed that both compounds enhanced heme-staining peptides with comparable electrophoretic mobilities. Moreover coadministration of MC (3 × 10 βmol · kg−1) and octachloronaphthalene (2 × 150 μmol · kg−1) indicated that their inductive effects were not additive. It was concluded that octachloronaphthalene was an MC-type inducer of hepatic microsomal enzymes.
Url:
DOI: 10.1016/0300-483X(81)90112-8
Affiliations:
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Safe</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>The Guelph-Waterloo Centre for Graduate Work in Chemistry, Department of Chemistry, University of Guelph, Guelph</wicri:regionArea><wicri:noRegion>Guelph</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="ISSN">0300-483X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1981">1981</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="123">123</biblScope><biblScope unit="page" to="132">132</biblScope></imprint><idno type="ISSN">0300-483X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Administration of octachloronaphthalene to immature male Wistar rats resulted in a dose-dependent increase in several enzymic, electrophoretic and spectral parameters associated with induction of the hepatic microsomal enzymes. Compared to corn-oil (control) treated animals octachloronaphthalene (150 μmol · kg−1 induced hepatic cytochrome P-450 (1.5-fold), benzo [a]pyrene hydroxylase (18-fold) and 4-chlorobiphenyl hydroxylase (18-fold) enzyme activities. In addition to increases in the relative peak intensities of the reduced microsomal cytochrome P-450 : CO and ethylisocyanide (EIC) difference spectra the peak maxima were observed at 448.5 and 452.2/428.0 nm, respectively. The effects of administering octachloronaphthalene to the rat were similar to those observed after pretreatment with 3-methylcholanthrene (MC) and electrophoresis of the induced microsomal proteins showed that both compounds enhanced heme-staining peptides with comparable electrophoretic mobilities. Moreover coadministration of MC (3 × 10 βmol · kg−1) and octachloronaphthalene (2 × 150 μmol · kg−1) indicated that their inductive effects were not additive. 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